Ipamorelin is widely considered one of the milder synthetic growth hormone releasing hormone (GHRH) analogs, with a very low incidence of reported side effects. It is classified as a pentapeptide based on the fact that there are five amino acid which form it structural chain. Regardless, even though the magnitude of effect while using Ipamorelin may be less pronounced than the stronger GHRHs, it is still widely accepted and used by athletes and other individuals desirous of improving their body composition, or for delivering its antiaging effects.
Effects Of Ipamorelin
Ipamorelin still maintains the effects you’re after when using a GHRH analog; primarily increasing natural growth hormone spikes and subsequently promoting a positive nitrogen balance, supporting muscle protein synthesis, enhancing the utilization of free fatty acids and supporting recuperation following training.
Sleep quality is also markedly better, as is the supportive action on structural tissue in the body, including joints, skin and hair.
Ipamorelin is similar to GHRP-6 in the sense that it stimulates ghrelin receptors, increasing the secretion of this hormone. However, their similarities end there. It does not increase appetite significantly, even though secretion of this hormone would indicate otherwise. Regardless, the stimulation of ghrelin receptors downstream contribute to an enhanced growth hormone surge, helping to compensate for its otherwise weak attributes.
Ipamorelin can also help to increase the number of growth hormone secreting cells, known as somatotropes, suppresses somatostatin and doesn’t affect corticosteroid hormones such as cortisol or aldosterone to a measurable degree. Prolactin related effects are also minimized since it does not increase production of this hormone.
Ipamorelin is administered either via the intramuscular route, or subcutaneously, at a frequency of 2 to 3 times daily. On average, 200 to 300 µg is administered per injection, with cycle lengths running for a minimum of eight weeks. However, it is not uncommon for cycles to continue indefinitely based on the fact that its safety profile is excellent. This is attributed to its lack of suppressing properties on endogenous hormones, including testosterone and growth hormone itself.
Possible Adverse Effects Of Ipamorelin
Ipamorelin is devoid of many of the common manifestations expected when using GHRH analogs, such as the possibility of prolactin induced gynecomastia, or even cortisol elevation. That is not to say that side effects do not occasionally occur, but when they do they are usually self-limiting and mild. They include the following:
Pain at the site of injection – it is a good idea to rotate injection sites frequently to prevent this.
Altered blood sugar levels – less intense than other GHRH analogs, but nevertheless still possible. May first manifest as lightheadedness or frequent headaches.
Ipamorelin is especially attractive if you’re looking to still elevate natural growth hormone production but at a level considered moderate when compared to other peptides, and with a frequency of side effects that is considerably less. Ipamorelin may also be preferred by people over the age of 35 who are desirous of embarking on a longer-term cycle of a GHRH to exert anti-aging effects.