GHRP-6 (Growth Hormone Releasing Peptide 6)

GHRP-6 is a first-generation growth hormone releasing peptide (GHRP), classified as hexa peptide, as a result of its 6 chain amino acid structure. The primary use of GHRP-6 is to stimulate the natural pulsatile growth hormone release patterns from the pituitary gland, allowing for effects to manifest.

It may be used alone, or combined with a growth hormone releasing hormone (GHRH) to increase the magnitude of growth hormone released at any one time. It may also be combined with exogenous HGH for synergistic action, though many people prefer it over exogenous administration of HGH which is suppressive of natural production.

Effects of GHRP-6

The effects attributed to GHRP-6 usage are those expected of growth hormone itself; increased muscle mass, positive nitrogen balance, reduced fat mass and optimized macronutrients metabolism and utilization. It is also sometimes used along with anabolic steroids to support joint and connective tissue health, accelerate recovery following an injury or especially when trying to gain a significant amount of body weight in a short period of time owing to its all-consuming appetite stimulating properties.

GHRP-6 Pharmacology

One of the primary modes of action behind GHRP-6’s actions are due to its ability to massively stimulate the hunger hormone ghrelin. The ghrelin receptor, sometimes known as growth hormone secretagogue receptor, in turn signals for an increased production of growth hormone by the pituitary gland.

In addition to this primary mechanism, it also suppresses somatostatin, the hormone that activates a negative feedback loop and turns off growth hormone production, and can help optimize subpar physiological levels of endogenous growth hormone.

GHRP-6 Dosage

GHRP-6 is best administered approximately 30 minutes before a meal, or at periods when blood glucose levels are believed to be the lowest (along with insulin). This is done since growth hormone has actions that are contrary to insulin, resulting in diminished efficacy of the peptide. Normal dosing frequency is three times per day, with a minimum of two being acceptable. Each injection should supply between 50 µg to 300 µg, though if combined with a growth hormone releasing hormone peptide this dose can be reduced.

Administration modes usually include subcutaneous or intramuscular route, based on individual preference.

Possible Adverse Effects Of GHRP-6

The major adverse effect of GHRP-6 is its massive appetite stimulating properties. Given, this can also be viewed as an advantage if you need to consume a significant number of calories, but it is less ideal to the average person who may be trying to achieve body recomposition or gain a moderate amount of weight.

Order adverse effects may include:

  • Increased levels of cortisol and prolactin – may precipitate gynecomastia in susceptible individuals
  • Increased cancer risk
  • Hypoglycemia – as a result of impaired glucose metabolism and enhanced usage of fatty acids

Summary

GHRP-6 remains one of the more powerful GHRPs on the market today, and is highly sought-after by athletes on a serious weight gain cycle. It is very effective in stimulating growth hormone production, and is in some ways a superior option to exogenous growth hormone itself as it possesses benefits that extend beyond the realms of growth hormone.