GHRP-2 (Growth Hormone Releasing Peptide 2)

GHRP-2, better known as growth hormone releasing peptide 2, is a growth hormone secretagogue which effectively increases the amount of growth hormone produced by the body. It is referred to as a hexa peptide, based on the fact that it consists of a six amino acid sequence structure.

It is closely related to GHRP-6, and shares many similar characteristics.

Effects of GHRP-2

The effects of GHRP-2 tend to mimic that of natural growth hormone in the sense that the effects manifested by it are attributed to the parent hormone itself. However, the way it does this is very interesting. In particular, a large degree of its actions is due to its ability to stimulate the production of ghrelin, otherwise known as the hunger hormone.

High levels of circulating ghrelin are associated with increased release of growth hormone, an effect believed to be embedded into our primal DNA for survival. Unknown to the body, it believes that you are starving, and increases the production of growth hormone in an attempt to help you survive. You will recall that growth hormone is a key antiaging hormone that can promote longevity – especially important during famine or periods of restricted food intake.

However, the beauty about GHRP-2 is the fact that you do not need to intensely restrict food; you still experience increased ghrelin release, hunger and the subsequent growth hormone surge.

Along with increased release of growth hormone, you can expect to experience increased muscle mass, reduced body fat and an enhanced metabolic profile.

GHRP-2 Pharmacology

Even though much of its actions are attributed to stimulating ghrelin, it does much more than this from a pharmacological standpoint. For instance, it can improve states of low growth hormone release; correcting the release pattern from the pituitary gland. In addition to this, it also helps reduce the impact of the hormone somatostatin, which impairs the natural release of growth hormone based on a negative feedback loop. Thus, GHRP-2 is well poised to exert a multipronged approach for increasing growth hormone levels.

GHRP-2 Dosage

GHRP-2 can be administered either subcutaneously (under the skin) or intramuscularly, though most people prefer to use the former mode of administration. The average dose of GHRP-2 is between 100 µg to 300 µg per injection, administered 1 to 4 times daily. This dose is not set in stone, however, based on individual needs and experience level.

Possible Adverse Effects Of GHRP-2

While GHRP-2 is considered a second-generation GHRP, and somewhat more tolerable than GHRP-6, it is still possible to experience the following:

  • Increased hunger- expected, but can be more than some users anticipate
  • Lethargy – owing to decreased usage of glucose and increased utilization of fatty acids for fuel
  • Increased cancer risk – owing to the fact that downstream it increases IGF-I production (which increases the risk of cancerous cell growth)

Summary

GHRP-2 is very effective for eliciting the release of growth hormone from the pituitary, and displays synergistic actions when combined with a GHRH peptide. It will not suppress natural growth hormone production in the manner synthetic HGH would, making it an attractive option for people a bit more invested in long-term health.